Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
  • Load image into Gallery viewer, Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
  • Load image into Gallery viewer, Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
  • Load image into Gallery viewer, Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
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Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba

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Mulateiro Video v02 by Ricardo Matrone
Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba
  • Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba

  • Nativilis MULATEIRO-EXTRAKTPULVER AUS DEM HEILIGEN CAPIRONA-BAUM – Calycophyllum spruceanum AMAZONISCHER BAUM DER JUGEND – Haarpflege – Anti-Aging-Antimykotikum – Wundheilende Eigenschaften – Copaiba


  • Capirona Tree  (pau-mulato) - This pioneer amazonian canopy tree grows 30 meters high and produces an abundance of small, white aromatic flowers. Once or twice a year, the tree sheds off its bark entirely avoiding lichens, fungi, epiphytes, and lianas. The smooth green bark underneath is somewhat like a sunburnt human. It is no surprise that the bark has been used in folk medicine as antifungal and antibacterial.  Shamans also use it as an admixture for the Ayahuasca brew. Modern science has found it is high in phenols and organic acids as well as antioxidants.

  • Mulateiro is a multi-purpose canopy tree in the Amazon. It grows tall and straight up to a height of about 30 meters and has been long used as a source of good, high-density lumber. Mulateiro is noted for its ability to completely shed and regenerate its bark on a yearly basis, turning the harvest of the bark totally renewable and sustainable.

  • Mulateiro bark contains a high amount of tannin chemicals which give it an astringent effect. Recently the plant has been documented to contain a high content of phenols and organic acids which have demonstrated antibacterial, antifungal and insecticidal activity. 
  • The isolated phenols have demonstrated strong antioxidant activity, which may explain its traditional use to stop the aging process of the skin. Another single substance called acetylenic acid (a long chain organic acid), proved to be the first antibiotic to be tested against bacteria and fungi. 
  • Mulateiro rejuvenates facial skin by combating wrinkles, eliminates expression lines caused by age. Reduces and brightens dark spots, which dermatologists call hyperpigmentation. 
  • In hair care it is used on shampoo to fight hair loss, strengthens and repairs brittle hair, restores the natural softness and brightness and strengthens the scalp. 
  • Known among forest communities as the "tree of youth" because of the constant renewal of its bark. Traditionally a decoction is made from the bark and applied to rejuvenate the skin, leaving it softer, beautiful and moisturized. Made a poultice from the bark it is applied topically in treating cuts, wounds and burns and believed to have antifungal and wound-healing qualities.

HARVEST PERIOD 

Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba

  • Aroma - Rich, smoky and bitter
  • Name: DRY EXTRACT OF MULATEIRO
  • Family: Rubiaceae
    Genus: Calycophyllum
    Species: spruceanum
    Synonyms: Calycophyllum multiflorum, Eukylista spruceana
    Common names: ashi, asho, capirona, capirona de bajo, capirona negra, corusicao, escorrega-macaco, firewood tree, mulateiro, mulateiro-da-várzea, naked tree, palo mulato, pau-marfim, pau mulato, pau-mulato-da-várzea, uhuachaunin, haxo, huiso asho, nahua
  • Botanical name: Calycophyllum spruceanum
  • Part of Plant: : Bark
  • Batch Number: AMO 105 - 002/082021
  • Number of analysis: 323/21
  • Cultivation: Wild
  • Country of Origin: Brazil
  • Major Compounds: Bio-actives: Phenols with strong antioxidant properties, Acetylene Acid, acts as natural medicine, and against fungi and bacteria , and rich in Mucilage, stimulates hair growth. (See the Certification  of Analysis)
  • Blends well with: Copaiba. Excellent base oil for any blend.

Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba

  • Directions for use: Can be used for facial and body moisturizing creams, as well as being used in handmade natural soaps, because its therapeutic and medicinal properties for facial and body skin, together with other natural moisturizers, expand its rejuvenating and restorative power of the skin.
  • Face exfoliant

    • Mix 1 1/2 tsp. of Nativilis MULATEIRO EXTRACT POWDER with 3/4 tsp. of purified water.
    • Wet your face, and apply the mixture to your skin.
    • Exfoliate using gentle circular motions for 30 seconds, then rinse with warm water.

    Face mask

    • Mix together 2 tsp. of Nativilis MULATEIRO EXTRACT POWDER , and 1/2 tsp. of purified water.
    • Apply the mask to clean, dry skin.
    • Leave on for 10–20 minutes.
    • Wash the mask off with a cleanser and towel dry.

    Hair mask

    • Mix 3 tbsp. of Nativilis MULATEIRO EXTRACT POWDER, 1 tbsp. of an oil of your choice, and 2 tsp. of purified water.
    • Apply mixture to the scalp and hair shaft.
    • Leave on for 5–15 minutes.
    • Wash the mask off with shampoo.
  • Anti Stretch Marks Serum – Dosage 5-20%
    Moisturizing creams – Dosage 3-10%
    Liquid soap – Dosage 0,5-3%
    Bar soaps – Dosage 1-5%
    Blend very well with Copaiba Oil
    Obs: 1 tsp (US teaspoon) = 5 ml = 5 gr / 1ml = 25 drops
  • Best Use: 12 Months
  • Shipping Weight:55g
  • SKU: SKU-MULATEIRO-5060864590920
  • Type: GTIN-13 - Number: 5060864590920
  • Volume: 50gr - 1.76 oz. (US)
  • Dimensions: Kraft Paper Window Stand Up Sealable Pouch with Zip Lock
  • Size : (110 x 185mm)
  • Safety data: External use recommended. Internal use under guidance from 
    a qualified practitioner. Keep away from children and eyes. Avoid if pregnant. Store in a cool dry place.  
  • Traditional Uses: for fungal infections of the skin (athlete's foot, nail fungus, etc.); for skin parasites; for Candida and yeast infections; as a skin aid for wrinkles, scars, freckles, and age spots; for diabetes

  • Benefits: Mulateiro bark contains a large amount of tannins that give it an astringent effect. Recently, the plant has been documented to contain a high content of phenols and organic acids that have demonstrated antibacterial, antifungal and insecticidal activity. Phenols demonstrate strong antioxidant activity, which may explain their traditional use to inhibit the skin’s aging process. Another substance called acetylenic acid (a long chain organic acid), has proven to be an antibiotic with action against bacteria and fungi. It rejuvenates the facial skin, eliminating the expression lines caused by age. Reduces and lightens dark spots, which dermatologists call hyperpigmentation. Strengthens and repairs brittle strands, restores natural softness and restores shine and strengthens the scalp.

PHYSICAL-CHEMICAL DATA AND APPLICATIONS

Mulateiro bark (Calycophyllum spruceanum) contains a high amount of tannin chemicals which give it an astringent effect. Recently the plant has been documented to contain a high content of phenols and organic acids which have demonstrated antibacterial, antifungal, and insecticidal activity. The isolated phenols have demonstrated strong antioxidant activity, which may explain its traditional use to stop the aging process of the skin.

Another single substance called acetylenic acid (a long chain organic acid) proved to be a first antibiotic to be tested against bacteria and fungi.

Mulateiro rejuvenates facial skin by combating wrinkles, eliminates expression lines caused by age. Reduces and brightens dark spots, which dermatologists call hyperpigmentation.

In hair care it is used ion shampoo to fight hair loss, strengthens and repairs brittle hair, restores the natural softness and brightness, and strengthen the scalp.

Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba

Mulateiro is a fascinating multi-purpose canopy tree in the Amazon. It grows tall and straight up to a height of about 30 meters, and has been long used as a source of good, high density lumber. It produces an abundance of small, white, aromatic flowers (from June to July) which are followed by elongated seed pods with 3-5 seeds inside. The tree propagates easily from the many seeds it produces. It can often be found near water as it can survive common periodic flooding in the region.

Mulateiro is noted for its ability to completely shed and regenerate its bark on a yearly basis, making harvesting the bark a totally renewable and sustainable enterprise. The bark is smooth (as if polished) and changes colors throughout the year as it matures - going from a green tone to a brownish tone. Calycophyllum is a small genus with only about 6 species spread through tropical America; all are medium-sized to large trees. This particular species is indigenous to the Amazon basin in Brazil, Peru, Bolivia and Ecuador. It is called mulateiro or pau-mulato in Brazil and it goes by name of capirona in Peru.

TRIBAL AND HERBAL MEDICINE USES

Mulateiro bark is deeply ingrained in the native culture - from being used as an admixture in the Ayahuasca rituals, to its many different uses in folkloric medicine. In the Amazon a poultice made from the bark is used topically in treating cuts, wounds and burns and believed to have antifungal and wound-healing qualities. The Indians also use a tea made from the bark on their bodies after bathing and then sun dry themselves. This forms a thin film covering their bodies believed to help fight the effects of aging, parasites and fungal infections. Indigenous people of the Amazon also use a bark decoction to treat diabetes. They boil 1 kg of bark in 10 liters of water until 4 liters remain. It is believed that if this decoction is drunk every day (about 5 ounces daily) for three consecutive months that it is a "cure" for diabetes. Peruvian tribes also apply the powdered bark to fungal infections of the skin. They also prepare a bark decoction to treat skin parasites - especially "sarna negra" - a nasty little bug that lives under the skin which is commonly found in the Amazon basin area.

In Peruvian herbal medicine today mulateiro is used for many purposes. A bark decoction is used topically for eye infections and infected wounds as well as for skin spots, skin depigmentation, wrinkles and scars. It also stops bleeding quickly and is often applied to bleeding cuts. Its also thought to soothe insect bites and reduce bruising and swelling. The bark is decocted and used internally for diabetes and disorders of the ovaries. The resin is used for abscesses, and skin tumors. Due to its beneficial effects to the skin, it is appearing as an ingredient in natural cosmetic products in Peru and Brazil.

Nativilis MULATEIRO EXTRACT POWDER FROM THE SACRED CAPIRONA TREE- Calycophyllum spruceanum - AMAZONIAN TREE OF YOUTH - Skin and Hair Care - Anti-aging - Antifungal - Wound-healing properties - Copaiba

PLANT CHEMICALS

 Mulateiro bark contains a great deal of tannin chemicals which give it an astringent or drying effect. Recently the plant has been documented to contain a high content of phenols and organic acids which have demonstrated antibacterial, antifungal and insecticidal activity. The isolated phenols have demonstrated strong antioxidant activity, which may explain its traditional use to stop the aging process of the skin.

BIOLOGICAL ACTIVITIES AND CLINICAL RESEARCH

 Only two studies have been published thus far on mulateiro. In 2001, researchers reported that it demonstrated strong antifungal activity in vitro against eleven common skin fungi and yeasts. In 2003, researchers reported the discovery of several new plant chemicals called seco-iridoids and reported that three of them were active against the tropical parasite, Trypansoma cruzi. With these studies, as well as the two groups of chemicals demonstrating antibacterial, antifungal, and insecticidal properties, scientists are just beginning to validate its traditional uses for various bacterial and fungal infections of the skin and as an insect repellent.


CURRENT PRACTICAL USES

 Mulateiro is better known today as a rainforest hardwood tree which is logged in the Amazon and exported around the world for high density, durable lumber and building materials, than as a medicinal plant. It has recently sparked the interest of scientists and formulators of natural body care products in South America for it beneficial effect to the skin. Even a branch of the Brazilian government is currently working with researchers and manufacturers about these new possible uses and markets for mulateiro bark in the body care products industry. With the tree shedding its bark annually, this resource would be highly sustainable. If a sufficient market were established for this renewable resource, then land owners would not cut them down for the value of the lumber and protect them for the income realized by annual harvesting of the bark. As a result of this work, mulateiro was been approved in the European Union as an ingredient employed in cosmetic products in February, 2006.

Mulateiro Plant Summary
Main Preparation Method: decoction

Main Actions (in order):
antifungal, anticandidal, astringent, insecticidal, wound healer

Main Uses:

  1. 1. for fungal infections of the skin (athlete's foot, nail fungus, etc.)
  2. 2. for skin parasites
  3. 3. for Candida and yeast infections
  4. 4. as a skin aid for wrinkles, scars, freckles, and age spots
  5. 5. for diabetes
Properties/Actions Documented by Research:
antibacterial, anticandidal, antifungal, antioxidant, insecticidal, insect repellant

Other Properties/Actions Documented by Traditional Use:
antidiabetic, antiparasitic, astringent, emollient, wound healer




Traditional Preparation: For external use, the standard remedy is ½ to 1 cup of standard decoction two to three times daily. This decoction is also a common topical remedy for skin problems, wounds, skin fungus, and overall skin health. It is applied directly to the affected area several times daily and allowed to dry before covering.

 

ECOLOGY

This species is a tree that occurs in dry forests and is native to most of Brazil. The tree gives off an aromatic fragrance, has a dark red bark, and grows to 10 to 20 meters in height and can be 50 to 60 centimeters in diameter at the base. When a cut is made in the trunk the resin exudes, which has a white-green color and a very pleasant, fragrant aroma. When the resin comes in contact with air, it hardens. The resin is collected from the trunk and the ground manually, all year round, but especially in the summer. After it is collected it must be dried in the shade and then stored in sacks made of fibers, such as jute. Cuts on a tree to extract the resin can be first made when the tree is 8 to 10 years old. To harvest the resin of this species sustainably, it is recommended that each tree receives only 2 to 3 cuts per year.

Yields vary according to the process of extraction. The process of hydrodistillation yields 11% resin whereas steam distillation yields approximately 2.5% resin. 

REFERENCES

Antioxidant Actions: 

Peixoto, H., et al "Calycophyllum spruceanum (Benth.), the Amazonian "Tree of Youth" prolongs longevity and enhances stress resistance in Caenorhabditis elegans." Molecules. 2018 Feb; 23(3): E534.

de Vargas, F., et al. "Antioxidant activity and peroxidase inhibition of Amazonian plants extracts traditionally used as anti-inflammatory." BMC Complement. Altern. Med. 2016 Feb; 16: 83.

Lino, T. et al. "Efeito antioxidante e fotoprotetor de extratos aquosos e etanólicos da casca do Calycophyllum spruceanum." In: Reunião Anual da SBPC - Sociedade Brasileira para o Progresso da Ciência, 61., 2009, Manaus. UFAM.

Antimicrobial & Antiparasitic Actions:Cardona Zuleta, L., et al. "Seco-iridoids from Calycophyllum spruceanum (Rubiaceae)." Phytochemistry. 2003 Sep;64(2): 549-53.

Portillo, A., et al. "Antifungal activity of Paraguayan plants used in traditional medicine." J. Ethnopharmacol. 2001 Jun; 76(1): 93-8.

Anti-aging Actions:

Peixoto, H., et al "Calycophyllum spruceanum (Benth.), the Amazonian "Tree of Youth" prolongs longevity and enhances stress resistance in Caenorhabditis elegans." Molecules. 2018 Feb; 23(3): E534.

Araújo, V., et al. "Mulateiro. In: Pastore Júnior, F. et al. [Plants of Amazonia for the production of cosmetics.]." ed. Brasília: Editora Universidade de Brasília, 2007, p. 42-44. 

LORENZI, H. Árvores brasileiras: manual de identificação e cultivo de plantas árboreas nativas do Brasil. Nova Odessa: Plantarum, 1992. 352p.  

MORAIS, L. R. : Banco de Dados Sobre Espécies Oleaginosas da Amazônia, não-publicado. 

ZULETA, L.M.C. et al (2003): Seco-iridoids from Calycophyllum spruceanum (Rubiaceae). Phytochemistry, v.64, p. 549-553, 2003. .

 

 


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